An Epitome of the History of Medicine

CHAPTER III.

Age of Transition (continued).—Arabic Period: A.D.640-1400.Alkindus, 873.Mesue, 777-857.Rhazes, 850-932.Haly-Abas, 994.Avicenna, 980-1037.Albucassis, 1122.Avenzoar, 1113-1161.Averroës, 11661198.Maimonides, 1135-1204.School of Salernum: Constantinus Afri-canus, 1018-1085.Roger of Salerno, 1210.Roland of Parma, 1250.The Four Masters, 1270 (?)John of Procida.

The Arabic Period, which began with the second destruction of the Alexandrian Library—640 A. D. —ends with the fourteenth century. At the commencement of this period the Roman Empire of the West scarcely existed: the magnificent territory which composed it had been overrun and subdued by barbarous tribes from the forests of the North, while from its ruins had risen several independent kingdoms,—that of the Franks in Gallia, of the Visigoths in Spain, and of the Lombards in Italy. The last of the Western emperors of note was Justinian, whose army and generals—especially the genius and heroic devotion of Belisarius—threw some glory upon Italy, Sicily, Africa, and Spain. Meantime the Empire of the East, surrounded by enemies, and harassed from all directions, still sustained itself with vigor. The Turks had begun to show themselves on the banks of the Danube; those eternal enemies of Rome—the Persians—made incessant war; and a new and terrible enemy had sprung up in the deserts of Arabia. Then came one who was at the same time legislator, prophet, and conqueror, and united under one faith and one leader tribes hitherto divided and warring against each other. Thus arose a powerful and enthusiastic nation, animated by thirst for conquest and ardor for proselytism. In less than a century after the first preaching of Mahomet, all of Arabia, India, Syria, and Egypt were in the hands of his followers. In the year 640 Amrou effected the conquest of Egypt, seized Alexandria, and the great library of five hundred thousand volumes was, by order of Omar (successor to Mahomet), delivered over to the flames; and the historian Abulpharagius declares that these books served for six months to heat the public baths, four thousand in number. Such were the first fruits of the establishment of Islam. * Happily, zeal of proselytism somewhat abated among the Mussulman princes, and religious fervor gave place to policy; so that the later Arabian caliphs showed themselves, in general, the protectors of the arts and sciences. Some, indeed, endeavored to collect the débris of the scattered treasures that had been so fortunate as to escape the ignorant fanaticism of their predecessors; and others, more tolerant even than the Christian princes of the time, received without distinction all men of merit who took refuge in their State, gave them employment, and recompensed them for their services. On this account philosophers and persecuted "heretics" sought an asylum among infidels, and found there the protection which Christianity did not afford,—in return for which they gave their protectors the benefits of Greek civilization.

     * See a very vigorous denial of this historical statement in      The Nineteenth Century, October, 1894, page 555.       

Of all the Moslem rulers, the most distinguished for love of learning and general enlightenment was Haroun-al-Raschid, the Charlemagne of the East, contemporary and emulator of the glory of the emperor of the Franks, the hero of a hundred Arabic poems, whose dominion extended from the borders of the Indus to the heart of the Spanish peninsula. He embellished Bagdad, his capital, with schools and hospitals. His son Almamon founded the Academy of Bagdad, which became the most celebrated of the age; likewise spared no pains to draw to his court the most illustrious men of all countries. He enjoined each of his ambassadors to purchase all the writings of the philosophers and physicians that could be found, and these he required to be translated into Arabic; his interpreter, Honain, a Christian, was employed at translating for forty-five years, and received, for each book rendered into Arabic, literally its weight in gold.

The eclat which the Moorish caliphs shed upon Spain from the tenth to the thirteenth century is well known. The cities of Cordova, Toledo, Seville, and Murcia possessed public libraries and academies, and students from all parts of Europe flocked to them to be instructed in arts and sciences; the library of Cordova alone embraced more than two hundred and twenty-four thousand volumes. Thus it will be seen that the dominion of mental and temporal affairs passed from the Greeks and Romans to the Saracens.

Arabian medicine constitutes one of the most interesting chapters in the history of our art. An offspring from Greek schools, it was for nearly one hundred years the fostermother of that art, and, although it gave rise to no great discovery nor wonderful step in advance during all this period, it nevertheless kept alive all the learning of the past, and clarified rather than made it turbid. In the sixth century the Nestorians (followers of Bishop Nestor), having been driven out of Syria, settled in Persia, Mesopotamia, and Arabia, and there founded schools and other institutions such as they had had at home,—schools in which, beside the ordinary philosophic studies, medicine received a share of attention. Thus it came about that by the seventh century Arabian physicians were everywhere known and in high repute. Naturally the basis for their studies embodied the writings of Hippocrates, Galen, Oribasius, and Paul of Ægina; and the first Arabian works consisted solely of translations from the Greek, first out of their Syriac rendering, and later from the originals. Indeed, so much eminence was finally achieved by Arabian physicians that more than four hundred are known by name as authors.

The first author deserving of mention was Bachtischua, of Nestorian stock, celebrated in Jondisapur, director of the medical school, and later physician to Caliph El-Mansur, in Bagdad. Of his descendants several became well known in the same field.

Alkindus—this being the Latin arrangement of his Arabic name—came from a Persian family, who lived first in Basara and later at the court of the caliphs El-Monon and El-Motasin, in Bagdad. He enjoyed a very high reputation as physician, philosopher, astronomer, and mathematician, and died A. D. 873. Mesue, the first of his name, sometimes known as Janus Damascenus, was director of the hospital in Bagdad and physician to Haroun-al-Raschid. He was born in 777, wrote extensively (since at least forty of his works have been catalogued), and died in 857 in Samarra.

Serapion the elder, also sometimes known as Janus Damascenus, and whose Arabic name was Serafiun, was born in Damascus—the exact data is not known—and died some time prior to A. D. 930. He was author of two volumes of aphorisms concerning the practice of medicine, which had at his time the greatest repute.

The most celebrated of the early Arabian physicians was Rhazes, born in the Persian province of Khorassan A. D. 850. According to the historians of his nation he was a universal genius, equally famous in music, astronomy, mathematics, chemistry, and medicine; he was surnamed "The Experienced." At the age of fifty he was one of the most distinguished professors in the Academy of Bagdad, where students came from great distances to listen to him. Chosen from among a hundred colleagues to direct the grand hospital of that city, he displayed indefatigable zeal and most scholarly learning, even to his old age and in spite of loss of sight, which overtook him at the age of eighty, when his reputation was at its height. Two years after this misfortune—i.e. , in 932—he died. His generosity, which was proverbial, and his compassion for the poor left him penniless at the time of his death. Some two hundred and thirty-seven monographs of his have been catalogued, though the greater number of his works are practically lost. Two treatises on medicine remain which afford excellent counsel in many respects; among other matters he advises:—

"Study carefully the antecedents of the man to whose care you propose to confide all you have most dear in this world,—that is, your life and the lives of your wife and children. If the man is dissipated, is given to frivolous pleasures, cultivates with too much zeal the arts foreign to his profession, still more if he be addicted to wine and debauchery, refrain from committing into such hands lives so precious."

His greatest publication was Continens—extracts compiled from all authors for his own use—divided into thirty-seven books, constituting an abridgment of the science of medicine and surgery up to his time; and, notwithstanding its imperfect state, this work was held in greatest reverence, and was a common source of knowledge among Orientals long after his day.

Haly-Abbas, a Persian by birth, flourished fifty years after Rhazes, and died A. D. 994. His Almalelci, in twenty volumes, constituted a quite complete system of theory and practice of medicine, which, however, was in large measure taken from Rhazes's Continens. It is generally regarded as the best work of any of the physicians of the Arabic Period; it is divided into three parts—a book on Health, a book on Death, and a book of Signs—and it is interesting to know that the portion devoted to midwifery and obstetrics was in the hands not only of the profession, but also of the midwives.

Avicenna—Latinized form of his Arabic name, Ebn Sina—was born in Bokhara in 980. From his earliest youth he manifested a remarkable disposition for scientific study, and it is claimed that he mastered the entire Koran at the age of ten years; also that he devoted his entire days and the greater part of his nights to research, mastering philosophy, mathematics, astronomy, and, later, medicine, which he studied at the university at Bagdad, in which city his talents were chiefly exhibited. He was received at court, loaded with favors, and elevated to the dignity of Vizier, but suddenly fell into disgrace, was deprived of property, imprisoned, and even threatened with execution. After two years, however, he was restored to liberty, and once more possessed the consideration of the public and the court, becoming the recipient of new honors. Meantime he had given himself up to intemperance, by which his previously robust constitution was undermined, and this, with excessive labor, brought about his demise at the too early age of fifty-six, in the year 1037. He was author of several books, the chief being the Canon Medicinae, which remained a classic for six centuries, constituting the medical code of Asia and Saracenic Europe; no author since Galen had enjoyed so wide and extensive authority in the medical world; and in the various medical schools professors, for the most part, confined themselves to reading the Canon from their desks, explaining and commenting upon its text. The work was divided into five volumes, of which the first two comprised the principles of physiology, pathology, hygiene, and therapeutics, arranged to conform to the teachings of Aristotle and Galen; the third and fourth dealt with treatment; and the fifth wras devoted to the preparation and composition of remedies. Avicenna appears to have surpassed in subtlety both Aristotle and Galen; he was fond of metaphysical speculation, and his works were too much filled out with subtleties of language rather than with true science. Authors of this period were fond of torturing in every way possible the writings which they undertook to edit or quote from, and, instead of devoting themselves to original research, wasted time in seeking for vague and hidden meanings. That man was most esteemed as learned who could see the greatest subtlety in some passage from one of the ancient writers; consequently, that which was obscure or unintelligible was deemed the most sublime and philosophic. A very brief study of the Canon, for instance, will show this, while in graphic pictures of disease the work by no means approaches those of Aretæus or Alexander of Tralles, for Avicenna too often contented himself with mentioning merely a list of symptoms without indicating in any way their progression, characters, or duration. Undoubtedly just was the criticism of an Arabian poet: "His philosophy had no sound foundation, and his medical knowledge availed him naught for the possession of personal health and long life."

Albucassis was born in Zahra, near Cordova, about the beginning of the eleventh century, and is supposed to have died A. D. 1122, at the advanced age of one hundred and one. He was author of an abridgment, or compilation, devoted to the practice of medicine, the only novelty of which is a small portion devoted to surgery, in which are described certain instruments. He says:—

"I have detailed briefly the methods of operations; I have described all necessary instruments, and I present their forms by means of drawings; in a word, I have omitted nothing of what can shed light to the profession.... But one of the principal reasons why it is so rare to meet a successful surgeon is that the apprenticeship of this branch is very long, and he who devotes himself to it must be versed in the science of anatomy, of which Galen has transmitted us the knowledge.... In fine, no one should permit himself to attempt this difficult art without having a perfept knowledge of anatomy and the action of remedies."

Not a word is said about dissections, however, from which we conclude that they were not tolerated in his time. He resorted enthusiastically to the cautery, and recommended it in spontaneous luxations and the commencement of curvature of the spine. He refers particularly to instrumental delivery and the extraction of the after-birth, and, when speaking of fractures and dislocations, he remarks: "This part of surgery has been abandoned to men of vulgar and uncultivated minds, for which reason it has fallen into undeserved contempt."

Original

Avenzoar, born in 1113, of a Spanish family which had many illustrious scions, was instructed in medicine by his father, and ultimately achieved great celebrity throughout Spain and Africa; for a time he lived at the court of the Prince of Seville, loaded with honors and presents, and finally was made Vizier. Among other works he wrote a treatise on renal diseases, in which he outlined the treatment of calculus and described an operation therefor. He died in 1161.

Averroës (as he is generally known, though his Arabic name was Aben Roschd) was born A. D. 1166, in Cordova, where his father held official position. After being grounded in philosophy, mathematics, and other sciences he became a pupil in medicine under Avenzoar. The greater part of his life wras passed in Seville, where he was greatly esteemed and finally knighted. In 1195 he was called to the court of the King of Spain and Morocco, in Cordova, where he received the highest honors, only, however, through some misunderstanding, to be disgraced; but he soon afterward recovered his former position and dignities. He wrote extensively not only on medicine, but on philosophy, his writings taking throughout a more or less dialectic character. He died in 1198, and from him descended a number of physicians who achieved more or less reputation.

Maimonides was born in Cordova, A. D. 1135. He early devoted himself to the Talmud, and in his extended travels visited Jerusalem; he even founded a school of philosophy in the East, which, however, had only a brief existence. He died in 1204. He ranked higher in philosophy than in medical art, and seems to have been imbued with the methods of his teacher, Averroës, and is generally regarded as a theorist rather than as a practical physician, although he wrote more or less on medical topics, and is particularly remembered for an essay upon poisons. He was about the last of the Arabians who deserves special mention.

During the period which was nearing its close at the time of the death of Maimonides, the Arabs embraced with much ardor the study of medicine, and translated into their language nearly all the treasures that had been amassed by the Greeks; indeed, the preservation of many of the great writings which would otherwise have been lost is due solely to this fact. Strange to say, however, the Arabians neglected Latin authors, and apparently possessed no knowledge of Celsus or Coelius Aurelianus. As religious prejudices prohibited dissections, they were obliged to rely solely upon the anatomical descriptions of Galen, and succeeded in increasing the errors of the original by inaccurate translations. So far as originality of observation goes, the Arabians were in most respects behind the Greeks; nevertheless, they were the first to differentiate eruptive fevers, to which the latter paid little or no attention. The Arabian school also supplied the knowledge of purgatives, such as cassia and manna, which replaced the drastics employed by the ancients; also the mode of preparation of syrups, tinctures, distilled waters, pomades, and plasters.

While the Arabians were gradually rising by their power, intelligence, and renown, the Greeks were declining in inverse ratio; the genius, courage, and ancient virtues of the latter grew weaker and weaker, until they seemed on the verge of extinction. In the medical history of these centuries, in all Europe not under Moslem rule, there was but one man entitled to mention as an author in medicine,—viz. , John Actuarius, the son of one Zacharia. He lived at the close of the thirteenth and the beginning of the fourteenth century; was employed at Constantinople, his surname being the honorary title of the court-physicians. He is more commonly known as Zacharia. Of his life we know little, save that he wrote several volumes, for the most part abridgments or commentaries on the doctrine of Galen. He laid great stress on the theory of critical days, and sustained his views by astronomical hypotheses most ingeniously combined. His was the first Greek work in which were mentioned the remedies introduced by the Arabians, yet he has not a word to say of variola, measles, spina ventosa, and other affections fully described by Arabic authors. He held remarkable views concerning the nature of man, whom he supposed to be formed by the union of two contrary substances,—the soul and the body; described somewhat elaborately an imaginary plexus of veins connected with the digestive organs, through which the animal spirits were elaborated and purified; also, and quite methodically, for his age, he explained the functions of the animal economy and the etiology of disease.

While the clouds that befogged the study of medicine in the Empire of the East thus grew heavier and heavier, we must not be blind to the melancholy spectacle concerning the provinces composing the Empire of the West. Barbarians in swarms, from the forests of Germany and Scandinavia, had swept its various portions, pillaging, destroying, and reducing to slavery its inhabitants. In southern Europe everything was changed. Each generation witnessed some new and unheard-of invader, who demanded his share of booty and renown and left a track of desolation behind him. There was a brief period of order when Charlemagne reunited under one dominion these divers races and seemed to have resuscitated the Western Empire; but no sooner was he dead than its elements, being devoid of affinity, broke apart. Former vassals, no longer restrained by the firm hand of the emperor, made common warfare against his successors and against each other, and for several ages there was nothing but a succession of wars and invasions. Feudalism gave some sort of character to this military anarchy by affording repose and, in a measure, security for those who had hitherto been trampled under foot; but learning and the sciences fell into complete neglect, and it was with great difficulty that a very small number of men found within the pale of the church a limited protection that enabled them to devote themselves to the study of medicine and ecclesiastical law. Near the end of the eleventh century, however, the enthusiasm of the crusades whetted anew the turbulent appetite of the Christian barons, and led these lords of western Europe, with their belligerent spirits, to the East, as a result of which people hitherto oppressed could breathe more freely. A few States recovered their independence; some semblance of law was established; municipal institutions were organized, and establishments consecrated to public use were founded and multiplied; finally, in the course of the thirteenth and fourteenth centuries, the cloud which covered the face of Roman Catholic Europe was in some measure dispersed, and men of talent and even genius began to appear upon the scene; everything about them being so obscure, they shone like stars in the firmament. In letters, for instance, there were Dante, Petrarch, Boccaccio; in mathematics, Leonard, of Pisa, the first in Europe to understand and employ figures and algebraic characters, although Cuvier has claimed this distinction for Gerbert, a Benedictine monk of the tenth century, who subsequently became Pope Sylvester II. At this time, although in scholastic estimation medicine, theology, and philosophy alone were fit to entertain the human mind, the natural sciences were not without occasional representatives. Roger Bacon was three centuries in advance of scientific reform, and endeavored to introduce experimental philosophy, and so fully convinced some of his auditors that they subscribed £2000 sterling to provide for the expense of his experiments; this was money most happily employed, since it made possible a number of important discoveries. It is said that Bacon knew the properties of convex and concave lenses, and was the first to conceive of the microscope and telescope; his astronomical knowledge led him to demand a reform in the calendar, which Gregory XIII carried out three centuries later; he had knowledge of gunpowder and its effects, and was, in fact, the wizard of his day; but his boldness and originality drew upon him the enmity of the church, by which he was persecuted and finally condemned to imprisonment for life upon a diet of bread and water, although he was ultimately released, in 1266, by Pope Clement IV. He wrote extensively, but only fragments of his works exist, since the friars believed them tainted with witchcraft and prevented their publication.

Before and during the time of Roger Bacon the philosophers were divided into two parties, which engaged in very unseemly and unphilosophic strife. One was termed the Realist, and believed, with Plato, that ideas are self-existent and independent of the mind,—in other words, veritable entities; the other, the Nominalist, held, with Aristotle, that general ideas are pure abstractions formed by the mind with the aid of sensations received from without, without which they could never exist,—that is, if a being could be imagined without sensibilities and the power of sensation, such being would be destitute of ideas. These two parties kept up a very active warfare, and enlisted the aid of both civil and ecclesiastical authorities, the result being persecution of each other, and that general unsatisfactory conflict into which theology and metaphysical speculation always force those who indulge in them.

Now, regarding the condition of medical affairs in the Empire of the West: Down to the seventh century, in Rome, there were court-archiaters who were attached to the retinues of the nobles, and in each large city popular archiaters formed a college charged with sanitary matters, the instruction and examination of candidates, and gratuitous services to the poor. Although there is little definite information available, it is probable that after the ruin of Alexandria much the same medical organization obtained in those provinces as continued under the Greek Empire at Constantinople. Under Arab sway we know very little of what rules or regulations governed instruction in medicine and its practice; and, so soon as one of these countries fell under the rule of the Turks, all scientific institutions seem to have decayed or been discontinued,—or, as Renouard states it: "If we may judge by what still exists to-day in this unfortunate country (Turkey), consumed by the power of ignorance and despotism, the most complete anarchy followed all older organizations."

In southern Europe, however, things had not gone on quite so badly, although at first barbarous invasion caused everywhere disorder and confusion, and the Christian States of the Western Empire yet presented after three or four centuries a chaotic condition of affairs. The ecclesiastical schools, which were under the care of the church, still pursued courses of literary and scientific instruction; in the time of Charlemagne, for instance, the colleges of the cathedrals, and even some of the monasteries, taught medicine in a very limited way under the name of physics. Thus all the liberal professions—that of medicine included—fell under the domination of the clergy, and priests, abbots, and bishops became court-physicians. The monks of Mount Cassin, of the order of St. Benoit, enjoyed for a long time a great reputation for medical skill; and among these in the tenth century was an abbot named Berthier Didier, who became Pope Victor III toward the close of the eleventh century, and one Constantine, surnamed the African. Of the ecclesiastics who from the ninth to the eleventh century were distinguished by the knowledge of medicine, there were Hugues, abbot of St. Denis, physician to the King of France; Didon, abbot of Sens; Sigoal, abbot of Epernay; Archbishop Milo, etc. Even several religious orders of women undertook, to a certain extent, the practice of medicine, and Hildegarde, who was abbess of the convent of Rupertsburg, near Bingen, is credited with having written a treatise on Materia Medica.

From the ninth to the thirteenth century the Jews shared with the clergy the monopoly of the healing art. Many of these studied under Arabian physicians, and, though the canons of the church forbade them to in any way minister to the ailments of Christians, they were still called upon in time of need, and even in many instances had access to the palaces of archbishops, cardinals, and popes.

The education of Christian priests and infidel practitioners embraced really very little, and consisted, for the most part, of knowledge of a few symptoms and possession of a few receipts; books were excessively rare and expensive, capable teachers lacking, and a good medical education out of the question. There was no law nor public regulation which concerned the practice of medicine, and any who desired could enter upon it; while besides the priests and the Jews—which latter stood at the top of the scale—there was a multitude of charlatans of the lowest order, such as barbers, keepers of baths, and even a few women. The morality of this vulgar herd was on a level with its knowledge. I have said the practice of medicine was not regulated by law, yet Theodoric, King of the Visigoths, enacted a statute that no physician should bleed a woman of noble birth without the assistance of a relative or domestic; that if a physician in treating a patient or dressing a wound happened to harm a gentleman he should pay a forfeit of one hundred sous, and if the patient died from the operation he should be handed over to the relatives of the deceased, who could do with him whatever they pleased; while if he crippled or caused the death of a serf, he was to be held accountable only for the loss, and compelled to supply another. This remained in force from the sixth to the twelfth century, and was made to apply chiefly to the practice of surgery, which had been abandoned to individuals of the lowest condition. The practice of internal medicine was, for the principal part, the privilege of the clergy, and it is not likely the secular power ever expected that one protected with the title of priest should be handed over to the relatives of the dead. It furthermore appears that the practice of medicine as divorced from surgery led to such irregularities in the manners and conduct of the clergy that from the twelfth century popes and councils of the church repeatedly forbade the medical art to those in holy orders or under vows; but that this prohibition was often violated is shown by the frequent reiteration of inhibitory laws. During the twelfth century the secular authority was also affected by abuses. Roger, founder of the kingdom of Sicily, one of the first Christian princes of the Middle Ages, gave special attention thereto, and in 1140 proclaimed that every one who wished to practice medicine must present himself before a magistrate and obtain authorization, under pain of imprisonment and confiscation of goods. Other sovereigns followed this example, and regulating ordinances were gradually established, which ultimately led to the institution of medical faculties and university degrees.

During the Middle Ages, in the Empire of the West, arose the School of Salernum, which became so celebrated that, like that of Alexandria, it deserves special mention. The modern city of Salerno is situated on the Neapolitan Gulf, about thirty miles southeast of the city of Naples, with a population of but a few thousand souls. The ancient city stood upon a height in the rear of the present town, where the ruins of its mediaeval citadel are still to be seen. It first appeared in history 194 B. C. , when a Roman colony was founded, was a municipal town of importance, and appears even at this early day to have been a health resort, since Horace informs us he had been advised to substitute its cool baths for the warm ones of Baiæ. During the stormy centuries following the downfall of the Western Empire, Salerno successively submitted to the sway of the Goths, Lombards, Franks, Saracens, and Greeks, as the vicissitudes of Avar compelled. Under the Lombards it became the residence of the Duke of Benevcntum, and, in 1075, when taken by Robert Guiscard of Normandy, it fell to the crown of Naples, in consequence of which in the fourteenth century, the heir apparent of this kingdom took the title of Prince of Salernum.

During the Middle Ages here flourished a medical school, important not alone because of its celebrity at the time, but for its effect upon the medical history of the future. Its origin is obscure, though it has been ascribed to Charlemagne in 802; again, its founding has been held to be the work of fugitives from Alexandria when that city was captured by the Saracens, 640 A. D. ; some attribute it to the Benedictine order of monks, others to Saracens, etc. The foundation by Alexandrian fugitives is probably conjectural, yet it must be admitted there is some evidence of knowledge of Arabian medicine in Salernum as early as this. Be the origin what it may, it is certain that the Benedictine monks exercised a very important influence upon this school, and there is considerable reason to think that it was really originated by them. Their monastery of Monte Casino was located about fifty miles the other side of Naples, occupying the site of an ancient temple of Apollo; the rules of the order enjoined the care of the sick and treatment by prayer, and St. Benedict himself was credited with performing miraculous cures. The rules which forbade public instruction were gradually discarded, for in the ninth century Abbot Bertharius wrote two books on the art of healing, and by the tenth century Monte Casino had acquired great reputation as a medical school, and was sought by medically-inclined monks from all quarters. A little later (1022) King Henry II, of Bavaria, Emperor of Germany, is said to have been cut for stone by St. Benedict himself, who appeared in ghostly form and operated with such skill that on awaking the royal patient found the calculus in his hand, and only the cicatrix of the wound through which it had been removed. Of course, the grateful emperor could do no less than richly endow the monastery, and bestow upon it additional privileges.

Desiderius, the Benedictine abbot from 1058 to 1086, and in the eleventh century promoted to the papal chair under the title of Victor III, was distinguished for his attainments in medicine and in music, and founded a new hospital in connection with the monastery; he also composed four books detailing the miraculous cures wrought by his patron saint. It was really within this monastery that Constantine the African, one of the most learned men and the most famous Christian physician of his time, compiled his numerous medical treatises.

About Constantine there is much of romance. He was born in Carthage in 1018 and died in 1085. He visited all the prominent schools of his day in Egypt, Bagdad, Babylon, and even India, and for thirty-nine years pursued the various branches of knowledge away from home. Returning to Carthage, misunderstood and feared, he was accused of practicing sorcery and compelled to fly to save his life. Disguised as a beggar he escaped to Salernum, which had been recently captured by Robert Guiscard, and on the recommendation of some royal visitor, who had known him at another court, he was made private secretary to Guiscard. His new duties soon became irkscme, however, and he retired to a cloister to devote himself to literary labors. These, for the most part, were translations of Greek and Arabic writings, often made verbatim and without credit. Whatever may be said about this lack of honesty, and the barbaric nature of his Latin, credit must be given him for reviving the study of Hippocrates and Galen in France; and he is generally credited with being the first to introduce into Europe knowledge of Arabian medicine.

From Monte Casino the Benedictines at an early day spread to Salernum, where, by the middle of the tenth century, three monasteries were established, in all of which were kept holy relics. It now appears that, although there may have been some previous institution of learning at this point, and possibly even medical teachers, the real organization of a regular school of medicine was due to the Benedictines. In the annals of Naples of the middle of the ninth century the names of Salernian physicians are mentioned; and it is known that toward the close of the tenth century Archbishop Verdun visited Salernum for relief from vesical calculus, and there died.

The earliest medical writings of this school which have been preserved are found in the Compendium Salernitanum, discovered in manuscript form in 1837; and among the more prominent authors quoted are: Petronius, who wrote about 1035; Gariopontus, who wrote about 1040; Bartholomæus, Ferrarius, and Affiacius,—the latter a disciple of Constantius Africanus.

The preaching of Peter the Hermit, which marked the close of the eleventh century, was followed by an outburst of crusading enthusiasm that quickly converted Europe into a vast camp, and Salernum, being situated upon the highroad to the East, was benefited in no small degree and its reputation as a medical school materially enhanced; likewise its teachers gained in experience as regards military surgery. In this way it became a favorite resort for crusaders when disabled, wounded, or diseased. Robert of Normandy, son of the conqueror, returning from the Holy Land, remained here for some time with a poisoned wound in the arm, received in 1097 at the siege of Jerusalem, and it was decided it could be healed only by sucking out the poison, a process deemed dangerous to the operator. History declares that Robert's wife, daughter of Goeffrey, Earl of Conversana, being denied permission, took advantage of her husband's unconsciousness during sleep to withdraw the poison, when the wound speedily healed. At the time of the departure of Robert, hastened by the death of his brother William, John of Milan, the then chief of the medical school, presented him with the famous Regimen Sanitatis Salerni, said to have been composed largely for Robert's benefit. This was a Latin poem that enjoyed most unexampled popularity for many generations, and was the vade mecum of well-educated physicians for centuries. It is said to have passed through two hundred and forty different editions, and that more than one hundred manuscript copies are to-day to be found in various European libraries. The latest English version was published by Professor Ordronaux in 1871. A sample is here submitted:—

"Salerno's school in conclave high unites

To counsel England's king, and thus indites:

If thou to health and vigor would'st attain,

Shun mighty cares; all anger deem profane;

From heavy suppers and much wine abstain;

Nor trivial count it after pompous fare

To rise from table and to take the air.

Shun idle noonday slumbers, nor delay

The urgent calls of nature to obey.

These rules if thou wilt follow to the end,

Thy life to greater length thou may'st extend."

During the twelfth and thirteenth centuries the glory of the School of Salerno reached its zenith; it was the most famous school of medicine in Europe, and was fostered by various kings. The celebrated Jew, Benjamin of Tudela, traveling from Spain to India, visited Salernum in 1164, and called it the "principal university of Christendom." Early in the twelfth century flourished Cophon, Archimatheus, and Nicholas, surnamed Præpositus, all of whom were distinguished teachers. The latter published a work known as Antidotarium, which was for several centuries the standard pharmacopoeia, and which contained a table of weights that corresponded very closely to those of the modern apothecary. The younger Cophon, who has been confounded with his father (as both seem to have written extensively), wrote two treatises,—one on the anatomy of the hog, the other entitled Ars Medendi. The first is interesting as the only anatomical treatise of this school which has been preserved, and is an index of the degradation of anatomical science of that time.

The names of John and Matthew Platearius are of frequent occurrence in the records of this school, and have given rise to considerable confusion; the former is supposed to have been the husband of Trotula, a female physician, of whom I shall have more to say later.

Bernard the Provincial, who seems to have escaped the notice of most historians, wrote about 1155, and his commentary offers much interesting information concerning the therapeutics of the day; he formulated a large number of recipes to enable the sick to escape the omnipotence of the apothecaries, and recommended wine for the delicate stomachs of the more exalted of the clergy, and, inasmuch as these stomachs did not bear medicine well, he directed, in accordance with the practice of Archbishop Æfanus, that emetics should be prescribed after meals, when their action is less injurious and more agreeable; he advised young men and women tormented with love which they could not gratify to tie their hands behind their backs and drink water from a vessel in which a red-hot iron had been cooled. Indeed, his work is full of curious information and advice, and is not without therapeutic interest.

A name which figures largely in the history of this school is that of Magister Salernus, about which there is great uncertainty; it is not positively known whether this refers to a particular person or is a generic name covering various individuals. The name has been mentioned as that of one of the four reputed founders of the school; it is positive that there are certain treatises which bear this name, which give an appearance of authenticity to it as an individual title.

In the latter half of the twelfth century lived John of St. Paul, one of the teachers of Gilbert the Englishman; also Musandinus, who left a curious treatise on dietetics; and Urso, who wrote on the pulse and on the urine. Here in 1190 resided and studied a certain Alcadinus, from Syracuse, whose knowledge of philosophy and medicine was such that he acquired great reputation, and was made a professor; he even composed Latin medical poems.

Just at the close of this century flourished Ægidius, who studied at Salernum, and also at Montpellier, where a school of medicine had been founded in 1180; he was physician to Philip Augustus, of France, and became professor in the University of Paris. Three treatises, all in Latin hexameter, are ascribed to him. A contemporary was Johanes Rogerus, of Palermo, a graduate of Salernum and author of several works.

Early in the thirteenth century flourished Roger of Parma, one of the most distinguished of the alumni of this school and the earliest pioneer in modern surgery; his work on this topic, familiarly known as Rogeriana, enjoyed the greatest reputation in its day, and was for a long time the surgical text-book of Italy; his predilection for poultices and moist dressings in the treatment of wounds, abscesses, and ulcers became, in the hands of his successors, the distinguishing feature of the surgery of Salernum in opposition to the school at Bologna, where Hugo Di Lucca and Theo-doric (his great rival) contended for the superiority of the dry treatment. Roger was also the first to use the term seton, and to give practical demonstration to this means of derivation.

Roland of Parma, a pupil of Roger, and a surgeon of great distinction, became professor at Bologna, and wrote a treatise on surgery, which was, for the most part, a commentary on the works of his master. The treatise of Roger and that of Roland furnished the basis for a work entitled The Treatise of the Four Masters, supposed to have been written about 1270, and manuscripts of which have been long known in various European libraries.It is divided into four books, displays no little surgical ability, and from its title would appear to have been the joint composition of four teachers; indeed, it was long attributed to Archimatheus, Platearius, Petro Cellus, and Affiacius, though it is now pretty generally understood to be the product of but a single pen and its author most likely a Frenchman.The ascription of authorship to four masters was probably for the purpose of increasing its weight and authority, and it constituted a reliable exposition of the surgery of Salernum in its day. It is quoted quite freely by Guy de Chauliac, who was the restorer of French surgery in the fourteenth century, and occasionally by later writers.

Another of the distinguished Salernian physicians of the thirteenth century, one highly esteemed by Frederick II, was John of Procida, who also was active in producing—if not the real author of—the massacre of the Sicilian Vespers, A. D. 1282. In a dispute concerning the question of the two Sicilies he embraced the cause of Prince Manfred, for which he was banished by Charles of Anjou, and took refuge at the court of Peter III, of Arragon, by whom he was created a baron; and he was influential in persuading the latter to assert his claim to the throne of Sicily. By various intrigues at different courts he succeeded in organizing an alliance, which betrayed its existence in this massacre, and finally resulted in the overthrow of the French in Sicily and the transfer of the island to the crown of Spain. He was author of at least two treatises devoted to medicine and philosophy.

Other writers of the School of Salernum were: a learned Jew of Agrigentum known as "Farragus," Matthew Sylvaticus, Graphæus, and Cappola. About the middle of the fifteenth century flourished Saladino, famous as an authority on materia medica.

It is of no small interest that now, for the first time in history, women began to figure somewhat prominently as writers, practitioners, and even teachers of medicine. About the middle of the eleventh century appeared a work, entitled De Midierium Passionibus, attributed to the before-mentioned Trotula, wife of John Platearius, which has descended even to these days. There is nothing in the work to indicate the name or sex of the author, who is invariably spoken of in the third person; consequently Trotula's connection therewith has often been disputed.

It mentions a certain "aqua mirabilis" composed largely of brandy, which spirit is said to have first been employed medicinally by Thaddeus of Florence, who died in 1295; there is also an account of a patient who wore spectacles! The diseases of women and children are also largely dealt with. The work is undoubtedly an anonymous production of the eleventh century, disfigured by additions of a later day, and ascribed to Trotula, perhaps, because of the celebrity that attached to her; at all events, it is the earliest work ascribed to a female physician, and thus possesses special claims to interest.

Later we read of Sichelguada, wife of Robert Guiscard and a graduate of Salernum, who endeavored to poison her step-son, Bohemond, in order to secure the succession of her own child. This infamous plot was furthered by some of the Salernian physicians, and thwarted only by the prompt action of Guiscard, who swore he would slay his wife with his own sword should the malady of Bohemond prove fatal.

Certain other female physicians of this period are mentioned, notably Abella, who, in spite of the modesty that is supposed to hedge about her sex, produced in Latin hexameter a work entitled De Natura Seminis Hominis. Mercuriolus, in the fifteenth century, produced treatises on the cure of wounds, pestilent fevers, and on the nails. The most celebrated of all, however, appears to have been Calenda, who lived during the reign of that notorious profligate, John II, of Naples (1414-1435), and who was particularly distinguished for her personal attractions. She graduated with great honor from the school at Salernum, and soon after, in 1423, married a nobleman of the court, which perhaps accounts for the fact that she never exercised the privilege of authorship. A little later, Marguerite, of Sicily or Naples, also a Salernian graduate, acquired an extended professional reputation, and was licensed to-practice by Ladislaus, King of Poland.

Daremberg informs us that there were numerous female physicians at Salernum, much sought after because of their talents, and, moreover, highly esteemed by the professors of the school, who freely quoted the writings of their fair pupils and contemporaries; further, that they employed ointments in paralyses; fumigations, vapors, and antimony for coughs; and lotions of aloe and rose-water for swellings of the face; they combined scientific knowledge with facetious playfulness in a manner peculiar to the sex, in that they tendered unsuspecting beaux bouquets of roses doctored with powdered euphorbium, and hugely enjoyed the forced sternutations of their victims.

It will thus be seen what a wide-spread and long-continued influence the school of Salernum exerted. At first physics and philosophy were the principal branches taught, but later the other sciences were cultivated. The Emperor Frederick II united the different schools of the city into a university,—a term, however, that, as then applied, appears to have corresponded to what in the nineteenth century is understood by corporation. The emperor likewise published several decrees which revised the duties and privileges of practitioners of medicine and surgery in his kingdom, and, in 1224, ordered that no person should practice within the two Sicilies until examined by the faculty of the university and licensed at the royal hands; further, practitioners were compelled to devote at least one year to the study of anatomy. The faculty at this time consisted of ten professors, whose salary probably depended upon the number of pupils. A candidate for graduation was required to present proof of majority, of legitimacy of birth, and of proper duration of preliminary study, and then was examined publicly in the Synopsis of Galen, the Aphorisms of Hippocrates, or the Canon of Avicenna. On passing he swore to conform to all the regulations hitherto observed in medicine, to give gratuitous treatment to the poor, and to expose all apothecaries detected in adulterating drugs. A book was then placed in his hands, a ring upon his finger, and a laurel crown upon his head, when he was "dismissed with a kiss." The degree conferred was that of "Magister"—the modern title of Doctor being at that period employed almost exclusively to designate a public teacher or professor.

But the watchfulness of King Frederick was not confined alone to the regulation of medical study within his kingdom. The number of professional visits, and the recompense therefor, were fixed by law. Every physician was compelled to visit his patients twice daily, and even once at night as well, if summoned, and for this attendance was permitted a daily fee equivalent to fourteen cents for patients within the city, while for calls without the city the largest legal charge was one dollar and thirteen cents, provided he paid his own expenses.

The earlier teachings and practice of Salernum were a curious mixture of methodism, dogmatism, and superstition. The latter may be better understood when it is recalled that the practice of medicine for an extended period was confined almost exclusively to ecclesiastics, who by their very education were prone to superstition and upheld the efficacy of charms and relics, and the active intervention of saints and martyrs as well as the myrmidons of evil; hence arose many of the conflicts and absurd notions peculiar to the period. The prevalence of the doctrine of medical methodism was due to the character of the writings most accessible to students of that day,—such as those of Ccelius Aurelianus and others; and it is curious that Celsus, the most elegant of medical authors, was never popular among medical monks. The Hellenic language having almost disappeared from Italy by the sixth century, the works of the Greek authors had become a sealed book to a vast majority, even of the better educated; hence the purer sources of medical knowledge were not available. Although the school of Salernum, at a later date, prided itself upon its devotion to the "Father of Medicine," the Hippocratic writings were not known at this period; and, when Constantine the African, by the translation of Arabian works, introduced a new element into the Salernian school, he ingrafted upon its medical teaching a form of doctrine which found a congenial atmosphere, in which it throve vigorously, while, a century later, the translations of Gerard of Cremona gave a stronger impulse to the growth of Hippocratic medicine than to Hippocratic doctrine.

From the Commentary of the Four Masters we learn that Salernian practitioners recognized the diagnostic importance of nausea, vomiting, and the flow of blood from the ears in injuries to the head; that they resorted to the trepan for depressed fractures and the relief of intracranial extravasation; that hernia cerebri was treated by pressure and caustics; that ligatures, both above and below the opening, were applied for the treatment of wounds of the carotid arteries and jugular veins. It was advised to decline patients suffering from wounds of the heart, lungs, diaphragm, stomach, or liver, in order to avoid the disgrace of losing them; and in penetrating wounds of the intestines and in those complicated with protrusion of the wounded gut instruction was given how to envelop them in the warm abdomen of a slaughtered animal until natural color and temperature were restored, and then to insert a cannula of alder-wood into the wounded intestine, which was to be neatly closed and stitched; finally, the protrusion was to be carefully washed with warm water and returned into the abdominal cavity, enlarging the opening for this purpose, if necessary. Also was advised the extraction of diseased teeth; and the operation of lithotomy was described with considerable care. Compound fractures were to be treated with splints. On the whole, this commentary of the alleged Four Masters is the most interesting and ancient Salernian work which has been preserved, and is well worthy the attention of even modern surgeons.

Such was the school of Salernum in its prime, during the twelfth and thirteenth centuries. My readers will not have failed to note how few names have been mentioned which are prominent in medical history, and how few improvements were made in medical art by those who have been mentioned. One naturally inquires, then, what was the source of the wide-spread fame of Salerno as a school, since it was distinguished neither by notable discovery in science nor by celebrated teachers, and the predominant element was doubtless one of obstinate conservatism and unswerving devotion to ancient doctrines. Founded during the dark period of the Middle Ages, at a time when ignorance, bigotry, and superstition prevailed, it preserved, amidst the gloom that had settled upon Europe, a few rays of that intellectual light which had shown so brightly in the golden ages of Roman history. These rays, made more conspicuous by the intellectual night which they barely illumined, were a beacon for men who were groping for more light. Thus the name of Salernum became synonymous with intellectual advancement in later ages. As the parent and model of our modern university system, Salernum yet deserves, in a measure, to enjoy the esteem of a numerous scholastic offspring. At a time when priests were particularly active in passing off rudimentary knowledge for the science of healing this school began to secure all information possible from the laity for the progressive development of medicine. It began, in other words, to hold aloof and then to break away from the fetters of a fanatical church. Its decline, too, was as rapid as its career had been brilliant. One very serious blow was struck when, in 1224, Frederick II founded the University of Naples and forbade Neapolitan subjects to seek instruction at any other university. The next year a revolt in the city provoked the closure of the schools of Bologna, which were, however, opened again two years later. Within a short time the universities of Naples, Montpellier, Padua, Paris, and Bologna all entered into a contest for pre-eminence with a rivalry which was not always generous. In 1224, it is said, the latter university had no less than ten thousand students. Happily, however, the period of the Renaissance proved to be one of emancipation from the fetters of ignorance and superstition, making an appeal for liberty which the conservatism of Salernum could not brook. Roger Bacon, in England; Lanfranc and Guy de Chauliac, in France; Mondino, at Bologna, and Savonarola, at Padua, found no rivals at Salernum to successfully contest their fame. Thus this ancient school fell behind the age, and in a short time sank into a mediocrity which was scarcely brightened by the reflection of a departed glory. In 1342 Robert I renewed the decree of Frederick II, which closed all the schools in his kingdom save those of Naples, but excepted Salernum solely because of its antiquity and the traditions of his predecessors. In 1413 King Ladislaus excepted the Salernian alumni and professors from all taxes, duties, and tribute. In the middle of the fourteenth century the poet Petrarch speaks of the school as a memory of the past; but its last appearance was in 1748, when a dispute at Paris relating to the rank of physicians and surgeons was referred to Salerno's university for arbitration and final decision. In 1811 a formal decree reduced this parent of all European universities to a mere gymnasium or preparatory school; and now one may wander through the streets of the modern town and among the ruins of its ancient predecessor and seek in vain to trace some reminder of those who were illustrious during some of the most terrible ages in the world's history. No echo of tradition, no stone of ancient edifice, no library preserving precious manuscripts, not even an edition of the old Salernian regimen, in the whole city; in fact, none now so poor as to do it reverence.

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CHAPTER IV.

Age of Transition (concluded).—The School of Montpellier: Raimond Lulli, 1235-1315.John of Gaddesden, 1305—(?)Arnold of Villanova, 12341313.Establishment of Various Universities.Gerard of Cremona, 1187.William of Salicet, 1280.Lanfranc, 1315.Mondino, 1275-1327.Guy de Chauliac, 1300-1370.Age of Renovation, 1400 to Present Time.—Erudite Period, including Fifteenth and Sixteenth Centuries.Thomas Linacre, 1461-1524.Sylvius, 1478-1555.Vesalius, 1514-1564.Columbus, 1490-1559.Eustachius, 1500-1574.Fallopius, 1523-1562.Fabricius ab Aquapendente, 1537-1619.Fabricius Hildanus, 1560-1634.

Although I have taken up so much time with an account of the school of Salernum, a few words must be devoted to the school of Montpellier, which was second in time and in importance among the great influences in the culture of western Europe. There was a time when to have studied there lent a special halo of glory, for, being near the sea, and in the vicinity of thermal baths, even so early as A. D. 1153 it was famous as a school of medicine; moreover, those who presided over it did not lapse unconditionally into mediæval philosophy, with its bewildering subtleties. It is said to have been founded A. D. 738, but first mention of it as a source of medical education occurs in 1137, when Bishop Adelbert II, of Mayence, visited the city to listen to its medical teachers. A faculty of philosophy was added in 1242, and one of law in 1298. Within the walls of the city sojourned both Christians and Jews, the latter being subject directly to the civil authorities, and particularly esteemed as translators. One of the most famous of the sons of Israel was Profatius Judicus, who became a rector of the faculty.

Prior to 1370, when the university became subject to the kings of France, it was under the control of the Pope; and then, as now, the school of medicine was the chief ornament of this ancient seat of learning.

One of the most illustrious and famous pupils of Montpellier was that religious mystic and alchemistic visionary, Raimond Lull, or Lulli, a would-be transmuter of metals and seeker for the philosopher's stone. Born in 1234, at the age of thirty he began to see visions, and was thereby roused from an atheistic tendency to soon become wonderfully pious; ultimately he entered the order of Minorites, studied Arabic, and appeared as a missionary in Africa, seeking to convert the Saracens—who, however, declined the honor, and finally (in 1315) rewarded his zeal by stoning him to death. Beside works on alchemy and theology, he wrote on medical subjects, and, like all great minds of the period, passed among the common people as a sorcerer in league with the devil. Nevertheless, he was a notable figure in his age and country.

Quite celebrated became the compendium of Gilbert of England (1290), which contained the same speculative nonsense, the same polypharmacy, and the same superstition as other works of that time; what little it contained of value was taken largely from other writers. While this Gilbert, often known as Gilbertus Anglicus, was not the first English writer on practical medicine, he was the earliest whose works have been preserved.

Still more famous was John Gaddesden, physician-in-ordinary to the King of England, professor in Merton College, Oxford, who wrote the famous treatise known as Rosa Anglica, which appeared between 1305 and 1315. This treatise was characterized by mysticism and disgusting therapeutic measures, and tainted by medical avarice, superstition, and charlatanry. Gaddesden was, perhaps, the first to formally recommend the "laying on of hands" by the king for the cure of scrofula (first performed by Edward the Confessor—1042-1056), whence comes the ancient name for this disease,—i.e. , "king's evil." *

     *A special "Service of Healing" was used in the English      Church under Henry VIII, 1484-1509.       

Arnold de Villeneuve (1234-1313) studied seven years at Montpellier, twenty years at Paris, visited all the universities in Italy, then went to Spain to levy on the Arabian authors. He wrote on medicine, theology and especially on chemistry—in which art he obtained great renown both as an author and teacher. To him is due the discovery of spirit of wine, oil of turpentine, aromatic waters, besides several preparations of less note, and the introduction of chemical compounds into therapeutics. His was a very stirring life, for he traveled extensively; he became a teacher at Bologna, and physician to Peter III, of Arragon. Shortly before his demise he went to Paris, having fallen under the ban because of a declaration that papal bulls, far from being sacredly inspired, were human works, and that acts of charity were dearer to God than hecatombs, etc. He finally perished by shipwreck, but the spirit of fanaticism followed him after death, for his volumes were condemned by the Inquisition, because they commended experiments rather than mere speculations. In spite of his general honesty in accordance with the spirit of the times he inculcated deceit in medicine, and one of his declarations is: "If thou canst not find anything in the examination of the renal secretion, declare that an obstruction of the liver exists. Particularly use the word 'obstruction,' since it is not understood, and it is of great importance that people should not understand what thou say est." He was one of the first to administer brandy, which he regarded as the elixir of life—whence the modern Eau de Vie.

Connected with this school, also, or well known as having studied there, were many men whose names became more or less famous—among them John Arden, who settled in London about the middle of the fourteenth century; Vinario, a contemporary of Guy de Cliauliac, and the well-known surgeon and anatomist Henri de Mondeville, who was a teacher of Guy de Chauliac. But an idea of the doctrines prevalent in the medical literature of this part of the world, at this time, may be had from the fact that most writers chose titles for their works after the style of ballad singers: for instance, those describing the plague and venereal diseases were called Flowers and Lilies of Medicine; the Rosa Anglica of John Gaddesden was another example. Matters had arrived at such a pass, indeed, that men of science no longer hesitated to confess superstition and mingle it openly with deceit, to oppose the interests of the most needy, and to extort from their fellow-creatures fees in proportion to their supposed ability to pay.

In the time of Charlemagne each cathedral possessed a school in which were taught arithmetic, theology, singing, and sometimes medicine; the Episcopal College had medical teachers who gave advice and dressed wounds at the doors of the Church of Notre Dame, Paris; but when the medical profession had been divorced from the sacerdotal by councils and popes, many of these cathedral schools closed. In order to preserve the jurisdiction which they for a long time had exercised over the learned professions, many were erected into universities, and thus the clergy gave instruction in philosophy, theology, and later in medicine. During the thirteenth century arose many of the great universities in Europe, notably those of Bologna, Padua, and Naples, in Italy; of Paris, Montpellier, and Toulouse, in France; of Valencia and Tortosa, in Spain; of Oxford, in England. Pope Innocent III by papal bull guaranteed that the professors and students at Paris should be exempt from all excommunications save those which emanated directly from the Holy See; French sovereigns conferred many privileges upon the universities, and soon the members of the University of Paris formed practically a second city, with its own laws, customs, police, citizens, and magistrates. Still, however, all science belonged to the clergy, and its teachers, though removed from the cloister, were none the less Roman Catholic; so that the popes reigned over the people through the parish clergy, and over the latter by the clerical teachers and professors. Nevertheless, in all candor it must be acknowledged that these studious men, thus associated together for mutual instruction and emulation in learning, contributed, in a large measure, to elevate Christian civilization above all others, though several generations were required to secure the results calculated to make men celebrated; hence the early periods of the universities developed very few names. Many were conspicuous by their love of instruction, but not by originality of research. Men undertook expensive and wearisome voyages without encouragement or hope of reward, simply to obtain some rare manuscript or to hear some renowned professor; and they appeal to us of the nineteenth century by their devotion, if not by the results of their work.

Among the somewhat scattered and more or less eminent men of this period was Gerard, of Cremona in Lombardy, a man of great purity and studiousness, who arduously pursued all that Latin authors could teach him, and, not being able to procure in Italy certain manuscripts which dated from the time of Ptolemy, determined to go to Toledo in search of an Arabian translation. At this time he was unacquainted with Arabic, but soon mastered it, and—armed with this powerful resource, which no other physician had possessed since the time of Constantine the African—he could not see so many Arabic works devoted to all branches of science as were gathered at the Spanish University without a desire to translate and transmit the same to his own country; hence he gave the remainder of his life to this work. He rendered into Latin the treatises of Hippocrates and Galen, of Serapion, and of all the famous Arabian authors from the time of Phazes, including the Canon of Avicenna and the work on surgery by Albucassis. He died at the age of seventy-three, in 1187, at Cremona, and left all his books to the monastery of St. Lucy, within whose walls he was buried.

William of Salicet, born at Plaisance in the first years of the thirteenth century, became a professor in the University of Bologna, and later at Verona. He wrote extensively on medicine, and earned a reputation as a surgeon that preserves his fame to the present day. It is claimed that his status in medical literature depends, in large measure, upon the fact that he was, perhaps, the first to refuse slavish obedience to preceding authors, preferring, instead, to draw upon the results of personal study and experience. He died in 1280.

Lanfranc, or Lanfranchi (according to whether one prefers his French or Italian name), studied under William of Salicet. Of his early life very little is known, save that he practiced surgery in Milan at the time of the great dissension between the Guelphs and Ghibellines, and, for attaching himself to the weaker party, was exiled and forced to seek an asylum in France; he resided in Lyons for several years, and here wrote a work on minor surgery; in 1295 he went to Paris on the invitation of the faculty of medicine, opened a course on surgery which met with great success, and then published a second and larger treatise on the subject. It is said of him by Malgaigne that, less from his fault perhaps than that of his age, after his death (about 1315) surgery began to decline. From the time of Brunus, who practiced in Padua in 1250, the barbers had done the scarifying and bleeding. After the time of Lanfranchi there were others who applied leeches and often cauteries, and even the women meddled with surgery and in all operations competed with the barbers; the lay surgeons held themselves rivals to the clergy. Lanfranchi inherited from his old master, William, an aversion for them all, and often had to contend with uneducated and incompetent laymen. Clerical surgeons regarded operations as beneath their dignity; and Lanfranchi, who deplored this condition of affairs, confessed he had sometimes bled with his own hands, but had never operated for ascites, hernia, cataract, or stone.

John Pitard has descended to fame not as a writer, but as the founder of the surgical schools of St. Come and St. Damien, which occupy so eminent a position in the surgical annals of France. In 1306 he was surgeon to the King of France, Philip le Bel, and the sworn surgeon of Chatelet. The College of St. Come, in 1311, was only a little brotherhood of lay-surgeons, who gradually grew in importance as the result of the obstinate struggles sustained,—on the one hand, against the faculty of medicine, and, on the other, against the barber-surgeons. Malgaigne has, with great patience and clearness, shown that the importance of this body of men has been greatly exaggerated by historians; he has traced their various turns of fortune from beginning to end; I shall have occasion to consider them again farther on.

Mondino, sometimes known as Mundinus, born in 1275, became a professor in the University of Bologna, and died in 1327. He was the author of a celebrated treatise on anatomy, said to have reached twenty-five editions, and which was the first of its kind since Galen. This science had been greatly neglected; in Salernum, for instance, they were, for a long time, contented with the treatise of Copho on the anatomy of the hog, and most of the anatomical knowledge of the age was apparently derived from this source; Mondino resurrected the study and pursued it with interest and enthusiasm, though under the greatest difficulties. His works for more than two centuries, along with the writings of Galen and the Arabic authors, served for anatomical demonstration, although very incomplete,—as witness the statement:—

"Beneath the veins of the forearm we see many muscles and many large and strong cords, of which it is not necessary to attempt the anatomy on such a corpse (i.e. , a recent one), but on one dried in the sun for three years, as I have shown otherwise, in developing the number and the anatomy of those of the superior and inferior extremity."

On the other hand, he took the opposite course to discover and demonstrate the nerves, and advised maceration in running water. It required almost superhuman boldness to substitute demonstrations on the human cadaver for those upon swine, yet this was done by Mondino; and at the time the prejudice against dissection was so general that for more than a century after Mondino—who died in 1327—no one dared, at least publicly, to emulate his example. It was in the year 1315 that he publicly dissected the bodies of two women in Bologna. Anatomical study was further complicated at this time by certain bulls of Pope Boniface VIII, forbidding evisceration or boiling or cooking any part of the human body; these deliverances were really aimed, not against scientific investigation, but at the absurd custom introduced by the crusaders of cutting up and boiling the bodies of their relatives who died in infidel countries, in order to send them home for burial in holy ground; nevertheless, the papal injunction certainly operated to discourage and prohibit anatomical dissection, since nearly two hundred years later the University of Tübingen was obliged to apply to Pope Sixtus IV for permission to authorize dissection.

Guy de Chauliac, born in Gévaudan about 1300. was the most famous physician and surgeon in Christendom during the Arabic period. He studied at the cathedral college of Mende, which at that time was quite celebrated, and was taught medicine at Montpellier under the best masters of his day. It is probable, also, that he studied in Paris, and certain that later, in Bologna, he saw dissections made. Dissatisfaction with the writings of the ancients and the knowledge which he obtained at the schools stimulated his own powers of observation, and he became, in every respect, an original student and acquired a degree of erudition far more extended than that possessed by any of his contemporaries. He practiced in various places, longest at Lyons; and finally entered the service of Pope Clement VI, at Avignon, and probably enjoyed the same honor under Innocent V and Urban V; when the latter was made pope, in 1362, de Chauliac became his chaplain, or chapel-reader. In 1363 he published a work on surgery called The Inventory, upon which his fame chiefly rests, though several other volumes emanated from his pen. None knew better than he how to unite respect for the ancients with justice toward contemporaries, and he cited a large number of Greek, Arabian, and Latin authors, some of whom are now utterly unknown. The sciences, he declared, are "created by successive additions; the same man cannot lay the foundation and perfect the superstructure. We are as children carried on the neck of a giant; aided by the labors of our predecessors we see all that they have seen, and something beside." In tracing the character of a surgeon he recommends that he be "learned, expert, ingenious, bold where he is sure, timid when in doubt, avoiding bad cures and practices, being gracious to the sick, generous and compassionate, wise in prediction, chaste, sober, pitiful, and merciful; not covetous nor extortionate, but receiving moderate fees according to the circumstances of his patients, the character of the case, and his own dignity."

"Never since Hippocrates," says Malgaigne, "has medicine learned a language stamped with such nobility and in such few words." Although a follower of Galen, in anatomy he insisted on the necessity of dissection, and proposed to make use of the corpses of executed criminals for this purpose. The drawings made by Henri de Mondeville were known to him; he divided abscesses into hot and cold, although among the latter he included oedcma, tympanites, dropsy, scirrhus, and other conditions. In practice he was more timid, yet more active, than Lan franchi, who never cut for stone, but left that operation to the traveling surgeons. De Ghauliac described it as he had seen it performed; he opened the abdomen for dropsy, did not hesitate to attempt the radical cure of hernia, and operated for cataract. The plague which raged during the fourteenth century and depopulated the known world of one-fourth of its inhabitants, twice appeared in Avignon while Guy de Chauliac was a resident there—and he acknowledges that nothing but shame prevented him from fleeing. He remained at his post, visited the sick, and was himself attacked and left for dead. "In this frightful position he had sufficient presence of mind to follow the peculiarities of his case, analyze his own sufferings, and to give a description of them worthy of Hippocrates" (Renouard). His work soon became the surgical code of Christendom, and was commented upon and translated into all tongues, remaining for a long time a classic, and even at this day it preserves much of its interest as representing the condition of medical science at the close of the Middle Ages; moreover, its literary style was much superior to that of any of his contemporaries, all of whom wrote very barbarous Latin. He died about 1370.

With the death of de Chauliac terminates our interest, not merely in the Arabian physicians and those who were intimately connected with them, but in the so-called Arabic Period. It may be added, in passing, that the followers of Mahomet, like those of Christ, erected by the side of each of their mosques a school, and often a hospital, endowed with more or less generosity by caliphs or the wealthy, who hoped to purchase redemption and eternal happiness by such liberality.

A certain number of religious orders or communities were established during the Middle Ages to give succor to the deserving sick, the most widely known being those of St. Mary; St. Lazarus; St. John, of Jerusalem; and the Daughters of God. To be sure, some, through the endowment of the opulent, became rich beyond all reason, and departed from their primitive purposes, and thus not only excited the covetousness of monarchs, but had even the temerity to resist their authority. This compelled, every now and again, a suppression of some order or institution—partly, perhaps, for laxity of morals, and partly because of their turbulence. Of this period it may be said that charitable zeal for the sick was never more pronounced; princes, bishops, and popes gave examples of devotion by dressing with their own hands the ulcers of lepers—and leprosy was in those days a frightful disease, having been contracted by the crusaders in the Orient, and everywhere spread as they returned, being, moreover, favored by the miserable uncleanliness which was then so common. Ignorance, dread, and fear rendered this disease worse than usual, and it was confounded with other maladies less formidable. It has been estimated that in the fifteenth century Europe harbored no less than nineteen thousand lepers; and that the disease was a great terror is manifest by the excessive caution taken against its spread: its victims were forbidden to enter cities, and on the highway were compelled to stand aside lest they should taint passers-by with their breath; even a healthy person convicted of being touched by a leper was banished from society; any infraction of these rules was punishable by death. It will thus be seen what depth of genuine humanity it required to have anything to do with one of these outcasts.

Another institution prevailed widely during these days,—namely, public baths, which were established in nearly every city and increased to such an extent that in the fifteenth century the bathers of Paris constituted a powerful brotherhood, so powerful, in fact, that Jacque Despars, physician to Charles VII, and one of the most renowned professors of the faculty, for speaking openly against the abuse of public baths, was obliged to leave the capital to avoid persecution.

A study of the general history of the Arabic Period reveals that the Arabs, previously obscure and uncivilized, emerged rapidly from the demi-savage state, and took the first rank among the polished nations of the world. During the earliest portion of this period these people were religious vandals and destructive fanatics, but later embraced with enthusiasm and persistence a study of the humanities, and endeavored to repair their early ravages by collecting the débris of the literary and scientific monuments of Greece; but, though they cultivated medicine with zeal and success, they added little to the Greek treasures. Later, Arabia was overrun by hordes from the deserts of Tartary, a people yet more barbarous and unknown, who established themselves in all parts of the globe then under Saracenic dominion, and by their brutal despotism degraded the Arabians to a condition approaching that from which they had emerged. This seems to have been ever the result of Turkish conquest.

Meanwhile the Greek nation, which was for so many ages at the head of civilization, gradually lost its power, virtue, courage, glory, and independence, and continued to descend, until now it exercises no influence whatever on the course of events. During the course of the Arabic Period only one Grecian physician merits mention on account of his writings, and in these there was nothing-new except what he had borrowed without credit from the Saracens.

The Empire of the West,—that is the western part of the ancient Roman Empire,—after subjugation by barbarians from Germany and Scandinavia, fell under a cloud whose darkness overwhelmed it. Its people, however, gradually received new life by commingling their blood with that of the invaders. Later they were able to repulse the Saracens who poured in upon them from Spain; then they turned their armies against each other, and wrought mutual havoc and ruin for several centuries. Again, roused by religious fanaticism, as had been the Mohammedans previously, they rushed by thousands upon the plains of Asia Minor, Syria, and Egypt, which had been for centuries occupied by the Arabs; and their adventures and enterprises, and the new and varied scenes through which they passed, gave rise among the "Francs" to some taste for poetry and works of imagination During the twelfth and thirteenth centuries governments became more stable, liberal institutions were created, the rust of ignorance gradually disappeared, and by the end of the Arabic Period there were really apparent brilliant streaks of mentality in the horizon of the nations of Europe. In this progressive movement the study of medicine shared. In the thirteenth century it was worthily represented in Italy, in Paris, and became established in Montpellier. Notwithstanding, up to this time physicians apparently only knew how to timidly follow in the track of the Arabians, and approached little, or not at all, in their studies, the purer lore of the Greeks.

THE AGE OF RENOVATION.

This Age of Renovation (extending from the commencement of the fifteenth century to the present time, according to Renouard's classification) is divided into the Erudite Period, comprising the fifteenth and sixteenth centuries, and the Reform Period, comprising the seventeenth and eighteenth centuries, and one should add, in fact, the nineteenth. In general literature this age is known as that of the Renaissance, and is one of whose beginning a great deal has been written, and so much better than I can put it in this brief work, that to general sources I should perhaps refer those who are interested in knowing how and why there came about such a tremendous change in methods and habits of thought and in acquirement of knowledge. But it is the history of medicine that at this time we particularly desire, and our minds must be, in some slight degree, prepared for the great changes to be recounted by some, with the conditions which brought about this revolution. It was truly an awakening in every department of knowledge and along every line of study; it was as if the minds of men had been dormant and lost their power of receptivity, and, after a long period of torpor, awakened in a new atmosphere amid new surroundings; as if there had burst upon them a sudden appreciation of ability to do things hitherto undreamed of, and to acquire knowledge such as hitherto had been possessed by none. Once free from the shackles imposed by authority of the past, these minds severed their Gothic bonds, and started forth in every direction with the ardor of youth and the interest of novelty, all engaging in the general enterprise of erecting from the débris of antique science a new temple to the mind in which to worship. While some delved among the records of the past, others sought to bind the past and present, and others, bolder yet, cut entirely loose from it, rejected all tradition, and would fain have built this temple with entirely new materials.

Now, what led to this sudden awakening? Was it chance, or the effect of certain causes which had long been operating'? It has been seen that hospitals and various institutions, whose foundations were dedicated to humanity, were erected in all parts of Europe; that gradually there had come about a better social organization; that there had been a diminution of conflicts between princes and their vassals, and the relations between the two were more nearly at an equilibrium. Moreover, the invention of the compass, which rendered long voyages less dangerous and more frequent, opened up to trade regions hitherto inaccessible or unknown, and attracted interest toward commerce as a means of pecuniary gain. The telescope had been invented, and astronomy was able to seize upon some of the facts by it revealed, and thereby to make more interesting calculations concerning the motions of celestial bodies, and attain a knowledge of our solar system and its laws. Gradually the microscope shed light upon the hitherto unseen; engraving on copper had added its power of illustration to the works of the great writers as they appeared; but above all, that which brought about this condition of affairs was the discovery of the art of printing. The first attempts in this direction were made between the years 1435 and 1440, and by the united efforts of three men, whose names deserve mention so long as their art persists,—namely, Guttenberg, Faust, and Shoeffer. Thanks to them, the same information could be multiplied in manifold form and transmitted to all parts of the civilized globe. In this way intelligence and reason become triumphant; thenceforward the dominion of brute force was broken, and knowledge, because capable of dissemination, became imperishable.

At the commencement of the Erudite Period Arabic literature still predominated in medicine. Rhazes, Haly-Abbas, and Avicenna were universally invoked and explained. But a taste for Greek literature began to prevail in the universities of Italy, and was finally extended to every part of Europe, especially after the taking of Constantinople by Mahomet II, Emperor of the Turks, in 1453. This disaster, which at first bade fair to be a mortal blow to Greek literature and language, strange to say, served only to hasten their resurrection in the Occident. Constantinople having been given over to pillage at this time, most of its learned men escaped, carrying with them all manuscripts that could be seized; most of these found refuge in Italy, and enlightened protectors in the allpowerful prince of the house of Medici, in Florence, in the popes at Rome, and in Alphonso, of Arragon, King of Naples and Sicily. Everywhere these fugitives spread the knowledge of the masterpieces of Greek literature and art, and in this way a taste for books, libraries, and sound erudition was diffused, while the Greek and Latin classics were hunted up and published with great patience and ardor; thus the works of the old writers were edited, translated, commented upon, and everywhere disseminated throughout Europe.

Among those who devoted themselves to the thankless task of editing, and purifying from interpolations, the works of the classic writers was Nicholas Léonicenus, born near Vincenza in the year 1428, who studied medicine at Padua and taught it for more than sixty years at Ferrara. He possessed great vigor of mind, with purity of manners and serenity of soul, and was the first to translate directly from Greek into Latin the aphorisms of Hippocrates and portions of the writings of Galen. He combated in every way the infatuation of his contemporaries for the Arabians and their lore, and called attention to many of the errors of men who, like Pliny the naturalist, had fallen for lack of fully understanding the Greek authors they compiled. At the ripe age of ninety-six he died, regretted by all.

Thomas Linacre, of Canterbury, a contemporary of Léonicenus, though younger (1461-1524), studied first at the University of Oxford, went to Italy in 1484, and in Florence attracted the attention of Lorenzo de Medici, who made him the companion of his own children, to whom he gave the best possible advantages. In due time he returned to England, where his talents speedily won him high station, and he became physician to King Henry VIII, and later to Queen Mary. Linacre was the first Englishman, it is said, who spoke purely the language of the Romans. He translated several books of Galen that are still esteemed; and caused the founding of two chairs, one at Oxford, the other at Cambridge, whose incumbents were charged with the duty of explaining the works of Hippocrates and Galen. But he is most entitled to the gratitude of his countrymen for his influence in founding the College of London. To appreciate properly its importance and his merits, we must remember the obstacles that had to be surmounted; for at that time bishops alone had the right to accord, in their own dioceses, permission to practice medicine, and, consequently, the healing art was abandoned entirely to monks and illiterate empirics. It was well that Linacre had influence at court, else he could never have obtained the reform of such overwhelming abuses; but he triumphed in spite of powerful opposition, and secured the issue of letters patent which prohibited the practice of medicine by any one who had not received a degree in one of the two universities in the kingdom, and been examined by the President of the College of London assisted by three others. This was the achievement which gave this learned man the title of "Restorer of Medicine" in England.

Léonicenus and Linacre, who were of the early Erudite Period, also merit mention not merely because of literary talents, but because they were the first eminent physicians to embrace the study of Greek classics, and to propagate the knowledge therein contained. Subsequently others followed the same course,—too many, in fact, to be enumerated; but it was easy to follow after such leaders. From the time when men began to realize the superiority of Greek models over prolix Arabian commentaries, they were anxious to seek the light at its source, and applied themselves with avidity to the study of the originals. At this time copies of Greek authors were few in number and in a deplorable condition, owing to neglect. To rediscover them, to purify, to eliminate what was not original, to rearrange, and finally to multiply by the aid of the printing-press was an extended labor requiring great knowledge, rare sagacity, and commendable patience. One of the greatest publications in medical literature belonging to this epoch was a complete edition of the Hippocratic writings, translated into Latin by Anuce Foes,—a poor, but learned, practitioner, who lived on the products of his business as pension physician in the city of Metz,—and issued from Frankfort-on-the-Main in 1495. To this master-work Foes consecrated forty years of his life. Another treatise belonging to this same time, less important, perhaps, from a medical point of view, but nevertheless showing great erudition, was a treatise on the gymnastics of the ancients, by Jerome Mercurial is, a work said to be not less precious to historians than antiquarians. It was by such intense zeal and hard labor that true erudition was restored in Europe.

Following now some of the special branches of medical learning and their development, let us look first at anatomy and physiology. I have already related the salient points of the life and labors of Mondino, of whom it is said that, about the year 1315, while professor at Bologna, he dissected the bodies of two women, and shortly after published an epitome of anatomy illustrated with wood-cuts. Also has been mentioned the prohibition of anatomical study pronounced by Pope Boniface VIII, in 1300. It was only toward the close of the fifteenth and the early years of the sixteenth century that this prejudice began to abate; the popes, who then stood at the head of scientific movements, withdrew their interdictions, and the universities of Italy gave public dissections. Achillini, Benedetti, and Jacques Berenger dissected at Bologna, Padua, and Pavia, previous to the year 1500; soon afterward their example was generally followed.

Jacques Dubois, whose name was Latinized into Jacobus Sylvius, was born in 1478, in a village near Amiens; he studied in Paris, where he worked most industriously at anatomy, which later he was so successful in teaching. He was the first to arrange all the muscles of the human body, to determine their functions, and to give names to those of them which had not yet been so designated. He discovered the valves of the large veins, and was the first to study the blood-vessels by means of colored injections. He gave the same careful attention to pharmacy, and in Paris, before a large class of students, began lectures, on anatomy, physiology, hygiene, pathology, and therapeutics; these he continued until the faculty, on account of jealousy, interrupted them. He then, in 1529, went to Montpellier, but returned two years later to become a member of the faculty, and once more lectured with the greatest eclat. Later yet he became a successor to Vidius in the Royal College,—a position he retained up to his death in 1555. His medical writings were extensive and marked by great accuracy, while for anatomy he did a great deal, contributing much to popularize it. He dissected a great number of animals and as many human cadavers as he could procure, the number, however, being small. Unfortunately, he subordinated all his own research to the authority of Galen, being himself among those anatomists who permitted themselves to be so far misled.

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The man of genius and courage, who accepted the truth of what his eyes revealed to him, and who was the true reformer in anatomy, was Andreas Vesalius, born at Brussels, in 1514, of a family already illustrious in medicine. He studied at the University of Louvain, where he early revealed the inclinations of the anatomist, since in his leisure moments he was wont to amuse himself in dissecting small animals. Near Louvain was a place where criminals were executed; and Vesalius, having observed the body of one from which the soft parts had all been cleaned away by ravenous birds, only the bones and ligaments remaining, detached the extremities separately, and then carried off the trunk by night, thus possessing himself of his first skeleton. Attracted by the fame of Sylvius, lie afterward went to Paris to become his pupil, but, not content with the lessons of his master, continued to observe for himself. On the hill Montfauçon, where executions took place, he disputed with dogs and vultures for the remains of criminals, or by stealth disinterred bodies from the cemeteries at the greatest personal risk. So great was his application that his progress became rapid, and at the age of twenty he gave instruction to fellow-students; at twenty-two he became Professor of Anatomy at Padua, being appointed by the Senate of Venice; at twenty-nine he issued his great work on anatomy, which showed a completeness that left far in the rear all that had hitherto been published on this subject. The following year he was called by the Emperor Charles V to the court of Madrid, then the most brilliant in Europe, where he became the first physictan, and from this time abandoned his anatomical labors.

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He was the first who dared to dispute the words of Galen and point out his errors,—to ascertain that the greater part of Galen's descriptions, having been made from monkeys, did not correctly represent human anatomy. This audacity raised a crowd of vehement opponents, the least reasonable and most fanatic being his old master, Sylvius; but even these onslaughts could not conceal the truth. The minds of men generally were ripe for the revolution whose signal-fire was thus lighted, and no sooner did Vesalius appeal from the decision of Galen to observation of nature than a crowd of anatomists were ready to follow his method. He died in 1564.

One who, at Padua, had been first his pupil, then his co-laborer,—namely, Columbus, born at Cremona in 1490,—succeeded him. Columbus criticised, in some respects, the statements of his eminent predecessor, which he could better do, since he is said to have dissected fourteen bodies every year, as well as to have practiced venesection. He came so near to discovering the mystery of the circulation that it is strange how he could have missed it. He even appreciated the systole and diastole of the heart and the connection thereof with dilatation and contraction of the arteries. He knew, also, that the pulmonary veins conducted arterial blood, and that the pericardium was a shut sac. He even appreciated the lesser circulation, since he described how the blood left the right side of the heart and passed into the lungs, and came back through the veins into the left ventricle; because of this discovery, and in spite of his utter failure to appreciate the greater circulation, he has been by some regarded as entitled to the credit which is universally given to Harvey. From his position as teacher in Padua Columbus was called to Pisa, and from Pisa to Rome, where he died in 1559.

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Another of the great anatomists of this period, second only in fame to Vesalius, was Eustachius, born about the beginning of the sixteenth century. He became physician to the Duke of Urbino, and in Rome a city physician and professor of anatomy, continuing to teach in the latter city until overtaken by his final sickness. He was a defender of Galen rather than an opponent, and sought to shelter his reputation from the attacks of Vesalius. In his praise it must be said that, for his day, he was a great anatomist; his chief discoveries were in the domain of comparative anatomy. He brought to bear upon his work a knowledge of embryology which enabled him, for instance, to describe the kidneys and the teeth much more accurately than would otherwise have been possible; he noted, also the pathological changes in bodies dissected, and is brought daily to our minds as we think of the connecting channel between the pharynx and the middle ear, to which his name has been given.

He died in 1574.

Fallopius, born in Modena, in 1523, was professor successively at Ferrara, Pisa, and Padua. He cultivated anatomy with the greatest ardor, and, in consequence, his name is also linked with that of Vesalius, as are those of Herophilus and Erasistratus in the history of ancient anatomy. His anatomical researches included all parts of the human body, and his name has been given to the tube through which the ovum enters the cavity of the uterus. Death overtook him in the year 1562.

Jerome Fabricius, better known as Fabricius ab Aquapendente, was born in the town of the latter name, near the southern end of the Apennines, in 1537, received his no early education in Padua, and studied anatomy under Fallopius, whose assistant he also was. After the death of the latter he succeeded to the professorship of anatomy, and later built, at his own expense, a large anatomical theater, in which he lectured and demonstrated to students from all parts of the world. Toward the end of his life he had accumulated a large number of specimens, and published extensively on anatomy, embryology, physiology, and surgery. Though often accredited with discovering the valves of the veins, he is not entitled to that honor, since Erasistratus, Sylvius, Vesalius, and others had previously described them, Estiennes had seen them in the azygos veins, and Canano in other veins. His true claim to glory rests upon embryological researches, which he was the first to undertake in a comparative way. In De Formato Foetu he elucidated the development of the embryo and its membranes by a long list of observations on lower animals of many species. He was probably the first to describe the uterine decidua. Fabricius died in 1619.

This Fabricius must not be confused with the almost-as-renowned Fabricius Hildanus, who was born in Hilden, near Düsseldorf, in 1560. Under the German name of Wilhelm Fabry he became widely known as a surgeon, and, after traveling through France, settled in Hilden, but later moved to Cologne, where he founded an academy. His first treatise—on gangrene and sphacelus—quickly made him known, and went through eleven editions. From Cologne he went successively to Genf, Lausanne, and Polen; returned to Cologne; and finally, after several other visits, settled in Bern, where he died of gout and asthma (in 1634.) . His frequent changes of location were, perhaps, less the result of instability than a testimony to his reputation, inasmuch as he was invited from one place to another. He has been, with propriety, named the "German Paré," since he rendered such great service to German surgery, and was not only an expert therein, but likewise a cultivated physician and polished humanitarian; in fact he was ahead of his time, by many years, in these regards, as is shown by his recommending amputation in cases of gangrene, and his writings concerning gunshot wounds. He enjoyed a ripe experience also in obstetrics, and even instructed his wife in the obstetric art and praised her ability most highly. His most important contributions to literature were in the field of surgery, and these passed through numerous editions, while his opinions and practice are quoted even to-day.

During this epoch many modifications were introduced and improvements made in the teaching of medicine. Permanent amphitheaters were established for dissection, and chairs of anatomy created, their incumbents being paid out of the public treasury. The popes, appear to have taken the initiative in this respect, which accounts for the great number of subjects with which Eustachius was supplied, as compared with Vesalius, who obtained only two or three in a year. Up to this time the razor had been the sole instrument of dissection, but was now replaced by the scalpel, which remains in use to-day.By the labors of the few men mentioned anatomy acquired a degree of perfection which it had never attained under the Greeks.Skillful artists put their labors upon paper, and plates and descriptions made from anatomical preparations represented the various parts of the human body with more fidelity than had been supposed possible.Nerves, tendons, and ligaments were no longer confused, but traced so far as possible from origin to ramifications.Ancient errors generally were corrected.It was proven that there was no bony structure in the tissue of the heart, that the partition between its cavities was not porous; and attentive examination of its valves led to the discovery of the lesser circulation by Columbus.Michael Servetus, whom John Calvin burned at the stake, was perhaps the first to note this phenomenon.He saw that the blood could not penetrate directly from the right into the left cavity of the heart, but that it was necessary for the whole fluid to pass through the lungs, where it became impregnated with the vital spirit of the atmosphere, and reached afterward the left auricle; the position of the valves in the pulmonary arteries and veins clearly confirmed his conjecture.Moreover the size of the pulmonary arteries was enormous, and disproportionate to the quantity of blood necessary for the nutrition of the lungs, which seemed to prove that this was not, as had been believed, the sole purpose of those vessels.It was about this time that Fabricius ab Aquapendente pointed out valves in veins in various parts of the body, and that Columbus and Andreas Cesalpinus explained more fully the mechanism of the lesser circulation; in fact, the former so closely approached an appreciation of the purpose of the vascular system that some have thought he really knew it, but the passages in his writings thought to sustain this opinion are not at all conclusive. He seems to have confused the action of the heart during sleep with that during the waking hours; and although he realized that the blood could not flow backward through the arteries, that the vena cava was the only vessel which permitted the entrance of blood into the heart, and though he spoke of anastomosis between arteries and veins and remarked that if a band be applied around a limb the veins swell below the ligature, he contented himself with comparing the motion of the blood with the flux and reflux of Euripus, as Aristotle had done. It is even thus that he tortured his mind in trying to reconcile two irreconcilable theories,—i.e. , the opinion of the ancients on the motion of the blood and recent discoveries in the anatomy of the vascular system.

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CHAPTER V.

Age of Renovation (continued).—Erudite Period (continued): Benivieni, 11502.Jean Fern el, 1497-1553.Porta, 1536-1615.Severino, 1580-1656.Incorporation of Brotherhood of St.Come into the University of Paris, 1515.Ambroise Paré, 1510-1590.Guillemeau, 1550-1613.Influence of the Occult Sciences: Agrippa, 1486-1535.Jerome Cardan, f 1501.Paracelsus, 14931541.Botal, born 1530.Joubert, 1529-1583.

In the domain of pathology the Arabs had added only a very small number of observations to those contained in the works of Galen. The most interesting of these pertain to eruptive fevers. Most of their writers contented themselves with making an inventory of the acquisitions of the past, as did Guy de Chauliac, and this was about all they could do under existing circumstances; although they did not make discoveries, they prepared the way for their successors.

Two men about this time did a great deal in the direction of creating a desire for post-mortem study of cases, and in illustrating and succinctly describing symptoms.

The first of these was Benivieni, a Florentine, who died in 1502—the date of his birth being uncertain. To him, more than to any other, we owe the commencement of the study of gross pathology and pathological anatomy. He was the first to consider the knowledge that might be obtained by opening bodies for the sole purpose of ascertaining the location and cause of the diseases from which they had died. As Malgaigne remarks: "A eulogy which he merits, and which he shared with no other person, and which has not been accorded to him up to this time by the many historians of surgery who have superficially searched among these precious sources, is that he was the first who had the habit, felt the need, and set the useful example, which he transmitted to his successors, of searching in the cadaver, according to the title of his book, for the concealed causes of disease." The work referred to by Malgaigne was entitled: Concerning Some of the Secret and Strange Causes of Disease and was published in Florence in 1507. It is poor in quotations, but rich in original observations, which pertain especially to the etiology of disease, and gives a very concise symptomatology and history of each affection of which it treats, as well as a pathological explanation. Benivieni's observations on gall-stone, on the anatomical lesions of heart diseases, and on the conveyance of syphilis from the mother to the foetus were original, as well as many observations concerning the presence of worms and other parasites in the body.

He did not limit himself to dissection of his own cases, but sought autopsies in the cases of others. He examined the bodies of those who had been hung, always thinking to find in them something of interest. In this regard he was followed by one already mentioned,—namely, Eustachius.

After these two the men who most cultivated pathology and anatomy in the sixteenth century were Rembert Dodoens and Marcellus Donatus. The former was born in 1517, in Mecheln, traveled extensively, was physician to Maximilian II and the Emperor Rudolph, and died in 1585. The latter lived and worked in the latter half of the sixteenth century, the dates of his birth and death being somewhat uncertain.

The next man whom we must mention is one who did a great deal for internal medicine, pathology, and anatomy. Jean Fernel, who has been surnamed "the modern Galen," was born in Clermont in 1497. Even as a boy he showed great aptitude, and very early made himself a reputation in philosophy, law, and mathematics. In 1530 he was received as doctor, with the unanimous applause of the entire faculty of Paris. He seems to have been stimulated by this only to more extended study; in fact, so hard did he work at his studies that his friends became seriously alarmed for his health, and remonstrated with him; they received for reply: "Destiny reserves for us repose enough."He became physician to King Henry II, of France, and in the midst of a very extensive practice undertook to collect all the medical knowledge scattered in the Greek, Arabic, and Latin works, in order to form from it a body of doctrines.His work was written with a purity and elegance of Latin that reminds one of Cicero.Throughout its pages he was philosophic, and sought to unite the apparently irreconcilable doctrines of Plato and Aristotle.

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He divided medical science into three great sections,—physiology, pathology, and therapeutics. In his explanations of disease he was too often fanciful, following the speculations mainly of Galen, and making free use of the hypotheses of humors, temperaments, vital spirits, etc.; but the following statement of his would do credit to a trained pathologist of to-day: "As for myself, I shall never believe I have profound knowledge of any affection if I do not know positively, just as if I could see it with my eyes, in what part of the human body is the disease, its primitive seat, what suspicion of organic lesions constitute it, whence it proceeded, if it exists idiopathically or by sympathy, or if it be kept up by some exterior cause. He who pretends to be a rational physician must sound each of these subjects, and discern them by certain signs." The problem which he thus set himself he certainly, for his own part, considered as solved, although it was not long before his solutions were set aside and the original uncertainty reappeared.

In therapeutics he very early laid down the fundamental maxim that every disease must be combated by contrary remedies, justifying this by every species of argument, amounting to this: that every disease must be combated by its contrary because all that cures a disease is contrary to it. This was, in part, the doctrine of "Contraria contrariis curantur"—the antithesis of the equally absurd sophism: "Similia similibus curantur" which three hundred years later was erected into an excuse for the foundation of an alleged new school. There can be no doubt that Fernel rendered very great service to his time and to subsequent generations, despite the fact that his recommendations and statements were too often founded upon sophistry.

Just here we must digress for a moment to consider the status of bleeding. Hippocrates and Galen had advised to bleed largely from the arm on the affected side in pleurisy and pneumonia. That practice was gradually abandoned as Greek traditions were lost sight of, and finally the Arabs substituted for it something entirely different,—namely, pricking a vein in the foot in order to let blood flow drop by drop. Their method prevailed throughout Europe until the commencement of the sixteenth century, or about the time when Fernel appeared upon the scene. A Parisian physician named Brissot had revived the ancient (the Greek) practice during an epidemic of pleurisy, and had obtained thereby astonishing success, which he hastened to publish, commending the method employed. He thus created a great uproar in the medical world. The innovation found foes and defenders, and disputes grew warm, even to the fever point. Finally, the ancient method was generally revived, and Fernel accepted it.

Felix Plater was born in 1536, in Basel, Switzerland, and died in 1614. He had several sons who made their mark in medicine. In his large work, which preceded that of Fernel, he took perhaps the first step in an unexplored route,—namely, in the classification of disease according to the totality of apparent symptoms. Defective as this classification appears in our eyes, its author lived a long life as a very distinguished practitioner and professor in his native town.

Giovanni Batista Porta was born in Naples in 1536, traveled extensively in Italy, France, and Spain, and founded in 1560 an Academy of the Segreti. He was accused of magic, and was compelled to refute the charges in Rome. He died in 1615, having been one of the leading scientists of his time, and the founder of modern optics. In the first edition of his Magia Naturalis, published in Naples, 1587, is found the first description of the camera obscura,—of course, in a very incomplete form and without lenses.

Severino was a celebrated surgeon of Naples. He was born in 1580, in Calabria, studied in Naples, became a doctor in Salernum, and then became professor of anatomy in his native town. For a long time the victim of intrigue and of persecution by the Inquisition, he was finally driven out of Naples, but was called back by the populace. He then became the most celebrated teacher of his time, writing extensively on a variety of subjects. He died in 1656 of the plague, an epidemic of which was at that time raging in central Italy.

Arriving now at the surgery of this Age, we find that matters were more chaotic than in other departments of medicine, and for reasons which are easily given and appreciated. While, ordinarily, external diseases are more easily discerned than internal, and while in a corresponding degree they can be more satisfactorily treated; while, in other words, external pathology has ordinarily taken precedence of internal in professional as in lay minds, this view seems to have been inverted for a time during the Middle Ages. Previous to the period now under discussion the sciences had generally declined in Europe, and surgery had fallen even lower than medicine, for the reason that medicine was in the hands of the priests, who had at that time something of a liberal education, while the practice of surgery was abandoned to a class of ignorant barbers, bathers, and bone-setters. No mechanic or artisan could take as an apprentice any youth without a certificate affirming his legitimate birth, and that he came from a family in which there were neither barbers, bath-keepers, shepherds, nor butchers. Among the men who were thus made social outcasts were those into whose hands most of the surgery of the fifteenth century fell. This was particularly the case in Germany, and other European countries were little in advance. We have seen that in France and in Italy Lanfranc and Guy de Chauliac did their best to rescue surgery from the hands of these men, but their efforts did not prevent it from being completely abandoned by the clergy, who devoted themselves to the practice of medicine.

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When we come to inquire the reason for this—in other words, why an art so useful as surgery, and one which made such requirements for knowledge, sagacity, and dexterity, whose necessity was almost continually felt, particularly during these troublous times of almost constant warfare, should be so neglected by men who could best comprehend its utility and respond to its requirements—it is difficult to find a satisfactory answer. The social condition of the times sheds some light upon the question. The nations of southern Europe were socially divided at that time into the nobility, who were nearly always at war; the clergy, who monopolized learning and filled the so-called liberal professions; and, finally, the common people, who were common prey for both the other classes, and who yet had to support both without having any privileges of their own. While the practice of medicine was a clerical right, the canon of the church prohibited physicians from drawing blood, under pain of excommunication; and hence surgery, shunned by the priests, to whom it naturally belonged in connection with the practice of medicine, fell into the hands of the ignorant and vulgar, who practiced it in a purely mechanical way, without knowledge or appreciation of its possibilities. In addition to this, there was an almost total lack of detailed and precise anatomical knowledge, and but small reason to expect that the ignorant practitioners of surgery would feel the need of such knowledge. Moreover, most of the operators were itinerants, going from city to city, stopping so long as they had cases to operate upon or until some reverse forced them to depart. Most of these men limited themselves to one or two sorts of operations. Some operated for cataract, others for stone, others for hernia, nearly every one having a secret method which was transmitted to his posterity as a heritage.

In the history of medicine certain family names of itinerant operators have been preserved; for example, the Branca, the Norsini, in Italy, and the Colot in France.

Under such conditions there could be no such thing as the profession of the surgeon. The prejudice against dissection did not begin to abate until the thirteenth century, when a very few of the clergy dared, in a very timid manner, to perform surgical operations. Their numbers increased in the course of the fourteenth and fifteenth centuries, and in the sixteenth had become considerable. Most of the great anatomists of that period—such as Benivieni, de Carpi, Vesalius, Fallopius, and Fabricius ab Aquapendente—were great surgeons.

In due time it came about that while the clerical physicians were willing to descend to the rank of operators, the lay-surgeons aspired to the rank of doctors of medicine. This transformation took place especially in France, the only country where at that time there was a special college of surgeons—the small Brotherhood of St. Come, already alluded to, which was always contending against the faculty on one hand and against the barber-surgeons on the other, with varying results, and which, at last, sought peace with the university and was received by it. This took place in 1515, and was the renaissance of surgery, not only for Paris, but for the whole world. By this reunion the faculty acquired authority over the barbers, who were admitted to their lectures and took courses in anatomy and surgery, gradually attaining a knowledge which entitled them to be called barber-surgeons; their rights were not curtailed, but made more difficult of procurement, for, in addition to passing their initiation for the privilege of becoming barbersurgeons, they also had to pass an examination before the physicians and the two surgeons of the king, at Chatelet, for the right to practice surgery. The surgeons, as the price of their submission to the faculty, had, beside the university privilege, a sort of supremacy over the barbers; and thus it happened that the barbers were admitted to the rank of surgeons at St. Come, and that the surgeons of St. Come were admitted as barber-surgeons by the faculty of medicine. In this double capacity they approached nearer the profession of medicine, from which they should never have been separated, while surgery became an art which received numerous improvements. We must now devote a little time to the consideration of at least two or three of the men who most contributed to extend and elevate it.

Among those who most contributed to make the period of which we are now speaking a glorious one, raising himself from the lowest walks of life to the attainment of the highest professional honors, is Ambroise Paré, whose name will never die while the art of surgery is taught. Paré was born about the year 1510, at Laval, of poor parents. He was an early apprentice to the provincial barber-surgeons, after which a natural ambition for improvement led him to Paris (about the year 1532), where he studied three years at the Hôtel-Dieu, and obtained the confidence of his teachers to such an extent that he sometimes operated for them. He never learned Latin, the language at that time of the books and of the schools. Paré was most fond of recalling his hospital experience; he counted it among the highest honors of his life that he should have enjoyed what he there did enjoy, and gives us to suppose that he was a favorite upon whom peculiar favors were conferred. In one of his writings, a physician of Milan having expressed astonishment at so young a man's knowledge, he remarks with pride: "But the good man did not know that I had been house-surgeon for three years at the Hôtel-Dieu de Paris." The functions of the barber apprentices in the hospital in those days were probably to make dressings and bleedings, and sometimes post-mortem examinations ordered by the chiefs, to assist the latter in their operations, and to act in case of emergency; in other words, to do about as the internes at present do. They probably found there a precious and rare opportunity for anatomical dissection, but it does not appear that they had regular clinical instruction.

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Communication between master and pupil depended absolutely on the pleasure of the former.

In 1537 Paré was made surgeon to the Colonel-General of Infantry, René de Montijean, with whom he made his first campaign in Italy. (This was in the army which King Francis I assembled in Provence with which to repulse the invasion of Charles V.) He had never seen war nor recent gunshot wounds, and only knew of them by what he had read in the writings of John de Vigo. This was at a time when it was the custom of surgeons to pour boiling oil into every amputation or other wound in order to check haemorrhage; and Paré's experience in this, his first campaign, put him in the way of his first discovery,—a discovery which will never be forgotten. He has recounted in his Book of Arquebus Wounds and in his great Apology how after the affair of Pas-de-Suze he watched the other surgeons, dreaming of nothing else but to imitate them as far as he could; how the boiling oil gave out; how his anxiety about it prevented him from sleeping; and how to his great wonder he found that the wounded who had submitted to the operation suffered more than the others. This set him to thinking, and led him, a young man without name or authority, without letters or philosophical studies, to observe, to reason, and to combat a doctrine which was universally admitted and which the highest surgical authorities of the day sustained. At that time all authors who had spoken of gunshot wounds considered them as poisonous and complicated with burns; consequently they gave the precept to cauterize with boiling oil or a red-hot iron, and at the same time to administer certain alexipharmics which should serve as internal antidotes. John de Vigo, physician to Pope Julius II, assures us that the danger of these wounds results from the round formation of the balls, from heat, and from the poisonous qualities communicated to them by the powder. His theory and the method of treatment above given had been adopted without contradiction until the day when Paré dared to utter the first protest against them.

After a campaign of three years, in which he lost his master, he returned to Paris and married. In 1543 he was in the army of Perpignan, in the service of de Rohan, grand lord of Brittany, where he gave continuous proof of his sagacity. It was after this campaign that his reputation, so well established among warriors and the nobility, inspired Sylvius with the desire of seeing him. Paré has recounted how, in a conversation which they had together, he insisted upon the then entirely new precept, of which he had made many applications, that in order to extract bullets it was best to place the wounded in the position in which they were at the moment of injury.

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Sylvius, then at the height of his fame, invited the young physician to dinner, and listened to him with great attention while he explained his views on gunshot wounds, which made such an impression upon the mind of the host that he besought him eagerly to write them out and make them public. Encouraged by this advice from so high a source, Paré prepared his text, illustrated it, and in the year 1545 brought out his little work, which marked in a manner so glorious the revival of French surgery. It was published by Gaulterot, the sworn bookseller of the University of Paris, and was entitled "The Manner of Treating Wounds made by Arquebuses and other Fire-arms, and those made by Arrows, Darts, and the Like; and also by Burns made Especially by Gunpowder. Composed by Ambroise Paré, Master Barber-Surgeon in Paris."

A few months later appeared the second edition, in which he still recommended the actual cautery in haemorrhage; but each day he meditated upon the subject, and on one occasion discussed it with two surgeons of St. Come, submitting to them the idea that, since ligatures were applied to veins and arteries, and to recent wounds, there was nothing to prevent their being equally applied to amputations. Both agreed with him, and opportunity soon presented itself at the siege of Damvilliers, when a gentleman had his leg crushed by a shot from the fortress. Paré made an amputation, omitting for the first time the use of the cautery, and had the happiness to save his patient, who, full of joy at having escaped the red-hot iron, said he had got clear of his leg on very good terms. This was, in truth, the actual renaissance of surgery, which had been to that time a torture, but which became thereafter a blessed art. It was a barber-surgeon who produced the double marvel. This took place in 1552.

In 1554, after other campaigns, Paré was made, without examination, Master of the College of St. Come, and in 1559 was included among the surgeons of King Henry II (who was killed in a tourney, in Paris, in 1559)r which position he retained with Francis II and Charles IX. The latter raised him to the highest position among his surgeons, and King Henry III retained him, which caused the witty and true remark that the kings of France transferred him to their successors as a legacy of the crown.

Many anecdotes are related of Paré to show the remarkable esteem in which he was held by public and private citizens. For instance, in October, 1552, one of the most eminent generals of Charles V laid seige to the city of Metz, and the emperor came in person to join the army. Within the walls of this beleaguered city were gathered nearly all the nobility and princes of France. The city was defended by the Duke of Guise, and the besieged soldiers were at that time suffering alike from the attacks of the enemy, the results of the siege, and the rigors of a frightful winter. The duke had established two hospitals for the soldiers, and had put into requisition the barber-surgeons of the city, giving them money with which to furnish their supplies. But these surgeons were sadly incompetent against the combination of unfavorable circumstances, consequently nearly all the wounded perished, and a horrible suspicion was roused among the soldiers that they had been poisoned. Under these circumstances the duke dispatched one of his captains to the king to say that the place could hold out for ten months, and asked at the same time for fresh medicine. The king sent for Paré, gave him money, directed him to take all the medicine he thought necessary, and furnished him a letter to Marshal St. Andre, who commanded in Verdun, and who bribed an Italian captain for fifteen hundred crowns to introduce into the besieged city the celebrated surgeon. The expedition was perilous, and Paré himself would have willingly remained in Paris. But he entered Metz on the 8th of December, at midnight, without an accident. Having passed already sixteen years in war, he was known to the chiefs and common soldiers. The day after his arrival, the duke, who knew how to strike the imagination, presented him on the ramparts to all the princes, lords, and captains, who embraced and received him with clamor. By the soldiers he was received with shouts of triumph. "We shall not die," they exclaimed; "even though wounded; Paré is among us!" From this time the defense was conducted with renewed vigor, and it has been universally conceded that to the presence of this single man the city was indebted for its salvation. The siege itself was not raised until after a terrific conflict. On the very day of Paré's arrival he began to treat the leg of one of the prominent officers, who for four days had been in charge of a charlatan, and had suffered horrible tortures. The next day he decided to trephine another, who had been struck on the head by a fragment of stone, and who had been insensible for fourteen days. Both patients recovered.